OSDC β Open Source Diabetes Classifier
Diabetes type classification in Danish register data
OSDC is an open source algorithm that classifies everyone in Denmark as having type 1 diabetes (T1D), type 2 diabetes (T2D) or no diabetes, based on data in the national registers.
Article: doi:10.2147/CLEP.S407019 Documentation and code: steno-aarhus.github.io/osdc
What does OSDC give you?
A pre-computed population with: - Diabetes type: T1D, T2D or no diabetes - Onset date: when the diabetes criteria were first met - Age at onset
The classification is based on a combination of diagnosis codes (LPR), medication information (LMDB) and laboratory results.
When is it used?
- To define a diabetes population as an exposure or inclusion criterion
- To exclude diabetes patients from a control group
- To classify type β LPR alone is not sufficient to reliably distinguish T1D from T2D
How to use OSDC
DARTER β project 708421 (pre-computed file)
On DARTER the OSDC classification is already computed and ready as an .rds file. You do not need to run the algorithm yourself.
# Load the pre-computed classification:
dm_pop <- readRDS("E:/workdata/708421/cleaned-data/diabetes-register-pop/dm_population_1977_2022.rds")
names(dm_pop)
# [1] "PNR" "diabetes_type" "do_dm" "age_at_onset"
library(dplyr)
dm_pop <- dm_pop %>% rename(pnr = PNR) # rename PNR to lowercase pnr
# diabetes_type: 1 = T1D, 2 = T2D | do_dm: onset dateExample: filter to T1D patients
t1d <- dm_pop %>%
filter(diabetes_type == 1) %>%
select(pnr, diabetes_type, do_dm) %>%
rename(date_diabetes = do_dm)Other projects β run the algorithm yourself
If your OSDC classification has not been pre-computed, you need to run the algorithm yourself.
Is the OSDC package available on DST for your project? It is not yet confirmed whether the osdc package (GitHub: steno-aarhus/osdc) is available in your projectβs CRAN snapshot. Check with "osdc" %in% rownames(installed.packages()) on the server. If it is not there, it must be imported via your data manager.
See documentation and installation guide at steno-aarhus.github.io/osdc.
Coverage and limitations
- The DARTER version covers diagnoses up to 2022 β check when your version was computed
- Classifies everyone in Denmark β not just your cohort
- Uses LPR, LMDB and laboratory results β requires access to these registers
See the full methodology in the article and documentation site.
Next steps
- Comorbidity adjustment with NMI? β Phase 14 β NMI
- Ready to export? β Phase 16 β Export and repatriation